Re-engineered around the operator for precision, comfort and control, day after day.
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The OTF7050 Cryostat is the next generation of Bright Instruments’ cryostat range, building on the proven performance of the OTF7000 and re-engineered around the operator. Four independently controlled refrigeration zones, a lower and more compact cabinet with a wider chamber, and a redesigned push-button and touchscreen interface bring a new level of comfort and precision to cryosectioning. From routine high-throughput pathology laboratories to time-critical applications such as Mohs micrographic surgery, it delivers consistent, high-quality sections across continuous daily use.
Available in two configurations, including the fully automated OTF7050A for enhanced workflow efficiency, the system is designed to perform predictably, day after day.
With multi-user accounts, device locking and full operation logging, the OTF7050 is equally at home in shared laboratories and core facilities, where many operators rely on the same instrument every day.
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Refrigeration on the OTF7050 spans four independently controlled zones – cryochamber, specimen head, blade holder and freezing station – driven by dual compressors for faster, quieter performance. Each zone can be set to suit the tissue in hand, so the optimum cutting temperature is reached quickly and held precisely. Even with the window open through a long session, chamber temperature is held within ±2°C for three hours or more, so the last sections of the day are cut in the same conditions as the first.
With its own cooling circuit, the blade holder reaches −35°C in just 7 minutes and holds it, independent of the chamber. A consistently cold blade gives cleaner, flatter sections first time, and blades stay sharp for longer. If ice builds up, the blade holder can be defrosted on its own while the rest of the chamber stays cold. This is particularly valuable in Mohs Surgery, where thin, consistent sections underpin reliable margin assessment.
The OTF7050 Cryostat is available in two configurations, including the fully automated OTF7050A, which supports repeatable motorised sectioning and greater workflow efficiency in high-use settings.
Specimens are frozen on the freezing station at a temperature chosen to suit the tissue, anywhere from −10 to −42°C. Fast, controlled freezing keeps tissue structure intact and gives a better block to cut from, while two CryoBar sites down to −60°C are on hand when a sample is urgent. With 23 freezing positions in total, the OTF7050 keeps several cases moving at once.
Every dimension of the OTF7050 has been reconsidered for comfort and access during long sectioning sessions.
A larger 10.1-inch touchscreen is paired with dedicated push-button panels for feed and temperature control. The functions used most are a single press away, keeping routine adjustments quick and simple. Section thickness, zone temperatures and system status are displayed together at a glance, with early warnings that help reduce maintenance.
The OTF7050 introduces account-level management, so a laboratory manager can control who uses the instrument and how.
The OTF7050 helps laboratories balance clinical demand with operational and sustainability goals, without compromising readiness or performance.
Integrated safety features help protect users, samples and the laboratory during routine operation and maintenance, particularly in busy clinical environments. They are designed to support safe handling, clear visibility and controlled operation without adding complexity to daily workflows.
The Bright Instruments OTF7050 cryostat is designed for laboratories that require reliable, high-quality frozen sectioning across both clinical and translational workflows. Its versatility supports a wide range of applications where precision, reproducibility, and dependable daily performance are essential.
Routine frozen sectioning requires predictable performance under time pressure. Independent control of chamber, specimen and blade temperatures, combined with smooth cutting behaviour, supports reliable section quality across a wide range of tissue types. This helps laboratories maintain turnaround times while supporting confident interpretation. Applications include intraoperative consultations for rapid diagnosis, margin assessment, tumour profiling, detection of metastasis and assessment of treatment response.
Mohs Surgery places unique demands on cryostat performance. Accurate margin assessment depends on thin, consistent sections produced rapidly and repeatedly during the procedure. Fast blade holder cooling, CryoBar sites for rapid freezing and fine sectioning control support reliable preparation of Mohs sections, helping surgeons and histotechnologists assess margins with confidence while maintaining procedural efficiency.
In busy clinical labs and core facilities, cryostats are often used by multiple operators across extended shifts. Instrument behaviour that changes with workload or technique can introduce variability and slow workflows. Stable multi-zone temperature control, personal temperature presets and multi-user management support consistent results across users and throughout the working day.
Neuroscience studies depend on well-preserved brain and nerve tissue, often across long series of sections. Precise temperature control and a stable sectioning mechanism support consistent serial sections for mapping neural structures and pathways.
Frozen sections are used in developmental biology to study organogenesis, cellular differentiation, stem cell research, and tissue engineering. Maintaining structural integrity during sectioning supports comparison across developmental stages and experimental conditions.
In pharmacological and toxicological studies, cryosectioning supports evaluation of therapeutic effects, tissue distribution, and early signs of toxicity. Reproducible section preparation is essential for comparing treated and control samples and for supporting translational interpretation.
Cryosectioned tissue is used to study immune cell distribution, inflammatory responses, pathogen localisation, and mechanisms of infection or autoimmune disease. Consistent section quality supports reliable spatial and cellular analysis.
Spatial transcriptomics and related techniques depend on accurate preservation of tissue architecture and RNA integrity. High-quality cryosectioning provides the foundation for successful data acquisition, supporting high-resolution mapping of gene expression within tissue context.
Across a wide range of non-infectious diseases, cryosectioning enables the study of disease progression, pathological features, cellular changes, and molecular mechanisms. Reliable frozen section preparation supports both clinical insight and translational research.
A cryostat is used for frozen sectioning in clinical pathology, including intraoperative diagnosis, margin assessment, and rapid tissue evaluation. It supports time-critical workflows where consistent section quality and predictable performance are essential for confident clinical interpretation.
Yes. Mohs Surgery requires rapid, repeatable preparation of thin, consistent sections for accurate margin assessment. Stable temperature control and fine sectioning performance offered by Bright Instruments OTF7050 Cryostat support reliable Mohs workflows across repeated cutting cycles during a procedure.
Temperature instability can lead to section artefacts such as compression, tearing, or inconsistent thickness. Stable temperature control, on the other hand, supports reproducible section quality, helping reduce re-cuts, wasted samples, and maintain turnaround times in busy clinical environments.
Cryostats are designed for continuous daily operation by multiple users. Predictable cutting behaviour, reliable recovery after workflow interruptions, and intuitive operation help maintain consistency across shifts and reduce operator-dependent variability.
Cryostats are suitable for a wide range of clinical tissue types encountered in pathology and Mohs Surgery. Consistent performance across varying tissue characteristics supports reliable frozen section preparation in everyday clinical use.
Motorised sectioning, such as in the OTF7050/A, supports repeatable and controlled cutting, which can help improve consistency and reduce operator fatigue during high-volume or repetitive workflows. This can be particularly beneficial in busy pathology laboratories and Mohs settings.
Clinical cryostats must support safe operation during routine use, clearing, and maintenance. Integrated safety features, clear visibility, and controlled operation help protect users without slowing down clinical workflows.
Many laboratories balance performance with sustainability and operating costs. Efficient cryostat operation, including reduced energy use during idle or sleep periods, supports lower running costs without compromising readiness for urgent clinical work.
The William Harvey Research Institute, part of Queen Mary, University of London, is conducting pioneering work at its Centre for Experimental Medicine and Rheumatology (EMR). EMR is the leading centre globally for biopsy-driven, stratified-medicine randomised clinical trials for rheumatoid arthritis. An existing Bright Instruments client, the EMR needed to upgrade its existing cryostat to boost operational efficiency. We were delighted to demonstrate the benefits that our latest OTF7050 Cryostat had to offer.
Cryostats are used in surgical diagnostic procedures and disease research to cut histological tissue sections. The set temperature employed by the cryostat will vary depending upon the tissue being cut. Typically, the cryostat chamber temperature will be set from -20○C to -30○C.
A technical demo can help you assess sectioning performance under conditions relevant to your research requirements. Get in touch with one of our experts to discuss your application.
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